Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Lyon (Gerland) | Prague (Central Bus Station Florenc) | Cheapest | ||||
| Bus | Lyon (Gerland) | Prague (Na Knížecí) | Fastest | ||||
| Bus | Aéroport LYS | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Aéroport LYS | Prague (Na Knížecí) | No tags | ||||
| Bus | Lyon (Gerland) | Prague (Central Bus Station Florenc) | No tags |
Last refresh of the prices: Yesterday at 7:54 PM CET.
Get from Lyon to Prague
The journey takes about 19 hours 10 minutes, and with fares starting at just $87, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lyon and Prague?
Stops in Lyon
- BRue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Stops in Prague
- ATomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- BAviatická, 161 08, Praha 6, Czechia
- C
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - DKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- EChlumecká, 198 00 Praha 20, Czech Republic
- F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling from Lyon to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Lyon to Prague?
The cheapest bus tickets from Lyon to Prague start from $87. The average price for this route is around $118. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
Which bus companies service the Lyon to Prague route?
Several major bus companies operate on this route with 10 buses available per day, including services from FlixBus, BlaBlaCar Bus, RegioJet.
What are the earliest and latest departure times for the bus from Lyon to Prague?
The earliest bus departs from Lyon to Prague at 12:20am. And the latest bus departs at 11:00pm.
What are the CO₂ emissions for the bus trip from Lyon to Prague?
A bus trip from Lyon to Prague generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Lyon to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1069 reviews.
Which bus company has the best Wi-Fi from Lyon to Prague?
Based on Busbud reviews, the bus company RegioJet has the highest Wi-Fi rating with a score of 3.8.
Which bus company has the best on-time performance from Lyon to Prague?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Lyon to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.4 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Prague was searched and found on Mar 23, 2026 with a price of $99To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Prague, as early as possible.
You can expect to pay from $99 to $211 for a bus ticket from Lyon to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $108 which is on 2026-03-28.
