Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Südseite Hauptbahnhof | PRG Airport | CheapestFastest | ||||
| Bus | Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Südseite Hauptbahnhof | Prague (Central Bus Station Florenc) | No tags |
Last refresh of the prices: Last Monday at 11:49 AM CET.
Compare 3 ways to go from Karlsruhe to Prague
Among the sustainable travel choices, the carpool stands out as a good way to reach Prague. The journey takes about 5 hours 10 minutes, and with fares starting at just $41, it presents an excellent value for a comfortable ride.
Where are the popular stops in Karlsruhe and Prague?
Stops in Karlsruhe
- AHinterm Hauptbahnhof 6, 76137 Karlsruhe, Germany
- BBahnhofpl. 1A, 76137 Karlsruhe, Germany
- CGoethestraße 17-19, 76135 Karlsruhe, Germany
- D
Karlsruhe
Gartenstraße 58, 76135 Karlsruhe, Germany - E
Karlsruhe/Baden-Baden Airport
Quebec Avenue, 77836 Rheinmünster, Germany
Stops in Prague
- AKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- B
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - CAviatická, 161 08, Praha 6, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about travelling from Karlsruhe to Prague by bus
What is the travel distance from Karlsruhe to Prague?
The distance between Karlsruhe and Prague is approximately 453 km (281 miles).
What are the departure and arrival locations for buses traveling from Karlsruhe to Prague?
Buses departing from Südseite Hauptbahnhof in Karlsruhe will take you to Florenc in Prague.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Karlsruhe to Prague was searched and found on Nov 24, 2025 with a price of $40To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Karlsruhe to Prague, as early as possible.
You can expect to pay from $40 to $107 for a bus ticket from Karlsruhe to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $40 which is on 2025-11-24.
