Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Florence, SC | Jacksonville Bus Station | Cheapest | ||||
| Bus | Bus station | Jacksonville Bus Station | Fastest |
Last refresh of the prices: Yesterday at 6:14 PM EDT.
Compare 2 ways to go from Florence to Jacksonville
Among the sustainable travel choices, the Bus stands out as a good way to reach Jacksonville. The journey takes about 5 hours 25 minutes, and with fares starting at just $66, it presents an excellent value for a comfortable ride.
Where are the popular stops in Florence and Jacksonville?
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
Compare bus companies
Based on 12305 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at $66
Frequently asked questions about travelling from Florence, SC, US to Jacksonville, FL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Jacksonville?
The cheapest bus tickets from Florence to Jacksonville start from $66. The average price for this route is around $77. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Jacksonville?
The average bus travel time from Florence to Jacksonville is 5h 25m, covering a distance of 466 km. The quickest bus can get you there in 5h 25m and is operated by FlixBus.
Which bus companies service the Florence to Jacksonville route?
Several major bus companies operate on this route with 1 buses available per day.
What are the earliest and latest departure times for the bus from Florence to Jacksonville?
The earliest bus departs from Florence to Jacksonville at 5:45am. And the latest bus departs at 4:00pm.
What are the CO₂ emissions for the bus trip from Florence to Jacksonville?
A bus trip from Florence to Jacksonville generates an estimated 12 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence, SC, US to Jacksonville, FL was searched and found on Mar 12, 2026 with a price of $62To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Jacksonville, FL, as early as possible.
You can expect to pay from $62 to $106 for a bus ticket from Florence, SC, US to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $62 which is on 2026-03-12.
What's the cheapest way to go from Florence, SC, US to Jacksonville, FL?
The Bus is the cheapest travel choice for this destination
