Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Viale Filippo Strozzi | Isernia | CheapestFastest | ||||
| Bus | Florence (Villa Costanza) | Isernia | No tags | ||||
| Bus | Florence (Villa Costanza) | Isernia | No tags | ||||
| Bus | Florence (Villa Costanza) | Isernia | No tags | ||||
| Bus | Viale Filippo Strozzi | Isernia | No tags |
Last refresh of the prices: Last Monday at 2:16 PM CET.
Compare 2 ways to go from Florence to Isernia
Among the sustainable travel choices, the carpool stands out as a good way to reach Isernia. The journey takes about 3 hours 50 minutes, and with fares starting at just $32, it presents an excellent value for a comfortable ride.
| Average Price | Average Duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average Price$53 - $109 | Average Duration10h 14m | 9kg CO₂e | ||
Carpool | Average Price$32 - $64 | Average Duration3h 50m | 14kg CO₂e |
Where are the popular stops in Florence and Isernia?
Stops in Florence
- A
Florence - Piazzale Montelungo
50129 Centro Storico FI, Italy - BA1 - Autostrada del Sole, 50018 Scandicci FI, Italy
- DVia della Costituzione, 185, 50018 Scandicci FI, Italy
- EPiazza della Stazione 45, 50123 Firenze, Italy
- FVia Cassia, 49B, 50023 Impruneta FI, Italy
Compare bus companies
Based on 11502 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $53
Frequently asked questions about travelling from Florence to Isernia by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Florence to Isernia?
The cheapest bus tickets from Florence to Isernia start from $53. The average price for this route is around $76. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Florence to Isernia?
The average bus travel time from Florence to Isernia is 10h 14m, covering a distance of 347 km. The quickest bus can get you there in 6h 55m and is operated by FlixBus.
Which bus companies service the Florence to Isernia route?
Several major bus companies operate on this route with 3 buses available per day.
What are the earliest and latest departure times for the bus from Florence to Isernia?
The earliest bus departs from Florence to Isernia at 1:10am. And the latest bus departs at 11:10pm.
What are the CO₂ emissions for the bus trip from Florence to Isernia?
A bus trip from Florence to Isernia generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Florence to Isernia was searched and found on Dec 5, 2025 with a price of $47To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence to Isernia, as early as possible.
You can expect to pay from $47 to $104 for a bus ticket from Florence to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at $47 which is on 2025-12-05.
