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One passenger / one way
- This trip is recommended because it is: CheapestDeparture time: August 8 atDeparture city: JacksonvilleDeparture location: Jacksonville Amtrak StationArrival time: August 11 atDestination city: St. LouisDestination location: Gateway StationOperated by: Amtrak
Vehicle: TrainDuration: - This trip is recommended because it is: FastestDeparture time: August 8 atDeparture city: JacksonvilleDeparture location: Jacksonville Amtrak StationArrival time: August 10 atDestination city: St. LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
- Departure time: August 8 atDeparture city: JacksonvilleDeparture location: Jacksonville Amtrak StationArrival time: August 10 atDestination city: St. LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
- Departure time: August 8 atDeparture city: JacksonvilleDeparture location: Jacksonville Amtrak StationArrival time: August 10 atDestination city: St. LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
- Departure time: August 8 atDeparture city: JacksonvilleDeparture location: Jacksonville Amtrak StationArrival time: August 10 atDestination city: St. LouisDestination location: Gateway StationOperated by: AmtrakVehicle: TrainDuration:
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Compare 2 ways to go from Jacksonville to St. Louis.
Busbud recommends taking the bus from Jacksonville to St. LouisAmong the sustainable travel choices, the bus stands out as the good way to reach St. Louis. The journey takes about 22 hours 15 minutes and with fares starting at just $85, it presents an excellent value for a comfortable ride.
Train Jacksonville, FL to St. Louis: Trip Overview
Please note, this information is subject to change.
Train Companies
Based on 5375 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $183
Jacksonville to St. Louis Train
Busbud shows you the best train ticket fares and train schedules so you can easily plan and book a trip by train from Jacksonville to St. Louis.
We make it our job to connect you with the most dependable companies that offer train service from Jacksonville to St. Louis.
From train tickets to high-end trains trip from Jacksonville to St. Louis, we offer a wide range of train services to best suit your needs depending on how much your budget is.
Where are the popular train stations and stops in Jacksonville, FL and St. Louis?
Frequently asked questions for your trip Jacksonville, FL - St. Louis
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Jacksonville, FL to St. Louis was searched and found on Aug 11, 2025 with a price of $249To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Jacksonville, FL to St. Louis, as early as possible.
You can expect to pay from $249 to $4,298 for a train ticket from Jacksonville, FL to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $249 which is on 2025-08-11.
About Train Travel
Train Travel Tips
Do you like to go fast? With high-speed trains going faster than 300 km/h on certain routes, the time will fly by. Taking a train between Jacksonville and St. Louis is also a great way to travel to arrive in the city centre and save more time for your stay in St. Louis.
Whether you take a regional or high-speed train to St. Louis, you’ll help reduce the environmental impact and carbon footprint of your trip. As you watch the landscapes unfold before your eyes, you can tell yourself that with this choice, you are making sure they remain protected.
The train emits up to 30x less CO2 for a trip between Jacksonville and St. Louis compared to the same trip made by plane or car. A truly ecological mode of transport that will allow you to easily reduce your carbon footprint.
Tune out to the fine sounds of your best music playlist on your train trip from Jacksonville to St. Louis while indulging in miles on end of beautiful scenic views.
Did you know?
Some trains in Sweden can recover more than a fifth of the energy they use by braking. This is especially true with ore trains as they descend from Narvik to Kiruna.
New York holds the record for the most platforms and track numbers in a single station. Grand Central Station in Manhattan is one of the largest rail terminals in the world with more than 44 platforms and 67 tracks to accommodate passengers.
Japanese trains are always on time, it is extremely infrequent to see breakdowns during peak periods. In the event of a delay of more than 5 minutes, the crew will personally apologize to each passenger.
Top Traveled Train Routes
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