Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Heinrich-von-Stephan-Straße 4-6 | Prague (Central Bus Station Florenc) | Cheapest | ||||
| Bus | Heinrich-von-Stephan-Straße 4-6 | Prague (Na Knížecí) | Fastest | ||||
| Bus | Heinrich-von-Stephan-Straße 4-6 | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Heinrich-von-Stephan-Straße 4-6 | Prague (Central Bus Station Florenc) | No tags | ||||
| Bus | Heinrich-von-Stephan-Straße 4-6 | Prague (Na Knížecí) | No tags |
Last refresh of the prices: Today at 1:23 AM CET.
Compare 3 ways to go from Mannheim to Prague
Among the sustainable travel choices, the carpool stands out as the good way to reach Prague. The journey takes about 4 hours 50 minutes and with fares starting at just $29, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mannheim and Prague?
Stops in Mannheim
- AHeinrich-von-Stephan-Straße 4-6, 68161 Mannheim, Germany
- BWilly-Brandt-Platz 17, 68161 Mannheim, Germany
- C
Uhlandstraße 7
Uhlandstraße 7, 68167 Mannheim, Germany
Stops in Prague
- AAviatická, 161 08, Praha 6, Czechia
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- E
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - F300/8 Wilsonova, 110 00 Praha, Czechia
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Frequently asked questions about traveling from Mannheim to Prague by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Mannheim to Prague?
The cheapest bus tickets from Mannheim to Prague start from $37. The average price for this route is around $49. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Mannheim to Prague?
The average bus trip duration from Mannheim to Prague is 7h 35m, covering a distance of 268 miles (431 km). The quickest bus can get you there in 6h 40m and is operated by FlixBus.
Which bus companies service the Mannheim to Prague route?
Several major bus companies operate on this route with 6 buses available per day, including services from FlixBus, BlaBlaCar Bus.
What is the earliest and latest departure time for the bus from Mannheim to Prague?
The earliest bus departs from Mannheim to Prague at 3:25am. And the latest bus departs at 3:50pm.
What are the CO₂ emissions for the bus trip from Mannheim to Prague?
A bus trip from Mannheim to Prague generates an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Mannheim to Prague?
According to Busbud customers, the highest-rated bus company on this route is BlaBlaCar Bus, with an average rating of 3.7 out of 5 stars based on 11143 reviews.
Which bus company has the best Wi-Fi from Mannheim to Prague?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Mannheim to Prague?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Mannheim to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is BlaBlaCar Bus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mannheim to Prague was searched and found on Dec 3, 2025 with a price of $36To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mannheim to Prague, as early as possible.
You can expect to pay from $36 to $96 for a bus ticket from Mannheim to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at $36 which is on 2025-12-03.
