Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | Durham Greyhound Bus Station | Cheapest | ||||
 | Bus | Indianapolis Bus Station | Durham Greyhound Bus Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Indianapolis Bus Station | Durham Greyhound Bus Station | No tags | ||||
| Bus | Indianapolis Bus Station | Durham Greyhound Bus Station | No tags | ||||
 | Bus | Downtown Transit Center | Durham Greyhound Bus Station | No tags |
Last refresh of the prices: Today at 9:34 AM EST.
Get from Indianapolis to Durham
The journey takes about 21 hours 40 minutes and with fares starting at just $146, it presents an excellent value for a comfortable ride.
Where are the popular stops in Indianapolis and Durham?
Stops in Durham
- A515 W Pettigrew St , Durham, NC 27703
- B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA - C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA - D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA
Compare bus companies
Frequently asked questions about traveling from Indianapolis to Durham, NC, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Indianapolis to Durham?
The cheapest bus tickets from Indianapolis to Durham start from $146. The average price for this route is around $186. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to Durham?
The average bus trip duration from Indianapolis to Durham is 21h 40m, covering a distance of 473 miles (762 km). The quickest bus can get you there in 20h and is operated by Greyhound.
Which bus companies service the Indianapolis to Durham route?
What is the earliest and latest departure time for the bus from Indianapolis to Durham?
The earliest bus departs from Indianapolis to Durham at 12:15am. And the latest bus departs at 11:30pm.
What are the CO₂ emissions for the bus trip from Indianapolis to Durham?
A bus trip from Indianapolis to Durham generates an estimated 19 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Indianapolis to Durham?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from Indianapolis to Durham?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Indianapolis to Durham?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to Durham?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Indianapolis to Durham, NC, US was searched and found on Dec 25, 2025 with a price of $181To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Durham, NC, US, as early as possible.
You can expect to pay from $181 to $209 for a bus ticket from Indianapolis to Durham, NC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $181 which is on 2025-12-25.
