Bus Tickets from Indianapolis to Buffalo, NY

Next departures

Next departures for Indianapolis to Buffalo on September 28
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Downtown Transit Center
Niagara Frontier Transportation AuthorityCheapestFastest
Amtrak
Greyhound Amtrak Station
Depew StationNo tags
Greyhound Lines, Inc.
Indianapolis Bus Station
Niagara Frontier Transportation AuthorityNo tags
FlixBus + Greyhound Lines, Inc.
Downtown Transit Center
Niagara Frontier Transportation AuthorityNo tags
Amtrak
Greyhound Amtrak Station
Depew StationNo tags

Last refresh of the prices: Last Wednesday at 12:05 PM EDT.

Accepted payments

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Compare 2 ways to go from Indianapolis to Buffalo.

Bus
Average Price$79 - $274Average Duration16h 45m
17kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$161 - $207Average Duration1d 2h
65kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Indianapolis to Buffalo

Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 16 hours 45 minutes and with fares starting at just $79, it presents an excellent value for a comfortable ride.

3bus per day
16h 45mAverage Duration
$79Cheapest ticket
17kgCO₂ emissions

Bus Indianapolis to Buffalo, NY: Trip Overview

Average ticket price$101
Average bus trip duration16h 45m
Number of daily buses3
Earliest bus departure12:25am
Distance434 miles (699 km)
Latest bus departure11:30pm

Indianapolis to Buffalo Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to Buffalo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Indianapolis to Buffalo.

Discover how much the bus trip from Indianapolis to Buffalo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Indianapolis - Buffalo, NY

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/25
$95
09/26
No data
Today
No data
09/28
$67
09/29
No data
09/30
$67
10/01
No data
10/02
No data
busbud logoThe cheapest trip from Indianapolis to Buffalo, NY was searched and found on Sep 30, 2025 with a price of $67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Buffalo, NY, as early as possible.

You can expect to pay from $67 to $640 for a bus ticket from Indianapolis to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-09-30.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Indianapolis to Buffalo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Indianapolis to Buffalo.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Indianapolis to Buffalo will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Indianapolis to Buffalo while indulging in miles on end of beautiful scenic views.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

What's the cheapest way to go from Indianapolis to Buffalo, NY?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Indianapolis by bus?

Bus from Buffalo, NY to Indianapolis

You can also go to Buffalo, NY by train

Train from Indianapolis to Buffalo, NY

Why choose Busbud?

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