Bus Tickets from Gainesville (FL) to Greenville (SC)

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TodayJun 5
TomorrowJun 6
from $99
SatJun 7
SunJun 8
MonJun 9
TueJun 10
WedJun 11
ThuJun 12

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest + Fastest
    Departure time: June 6 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: June 6 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: June 6 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: Gainesville
    Departure location: Gainesville Bus Stop
    Arrival time: June 7 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: June 6 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: June 6 at
    Departure city: Gainesville
    Departure location: Rosa Parks Station
    Arrival time: June 6 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Gainesville to Greenville: Trip Overview

Average ticket price$91
Average bus trip duration12h 25m
Number of daily buses7
Earliest bus departure1:10am
Distance353 miles (569 km)
Latest bus departure8:00pm

Gainesville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Greenville.

From cheap bus tickets to more luxurious buses traveling from Gainesville to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Gainesville (FL) - Greenville (SC)

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/03
No data
06/04
No data
Today
No data
06/06
$93
06/07
No data
06/08
$68
06/09
$67
06/10
No data
busbud logoThe cheapest trip from Gainesville to Greenville was searched and found on Jun 9, 2025 with a price of $67

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville to Greenville, as early as possible.

You can expect to pay from $67 to $128 for a bus ticket from Gainesville to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-06-09.

Usually Greyhound Lines, Inc. will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Gainesville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Gainesville to Greenville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Gainesville to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Gainesville to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Gainesville by bus?

Bus from Gainesville to Greenville

You can also go to Greenville by train

Train from Gainesville to Greenville

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