Bus Tickets from Gainesville, FL to Greenville, SC

Next departures

Next departures for Gainesville to Greenville on September 23
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Gainesville Bus Stop
1116 Woodruff RdCheapest
FlixBus + Greyhound Lines, Inc.
Rosa Parks Station
1116 Woodruff RdFastest
Greyhound Lines, Inc.
Gainesville Bus Stop
1116 Woodruff RdNo tags
FlixBus
Rosa Parks Station
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Rosa Parks Station
1116 Woodruff RdNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Gainesville, FL to Greenville, SC: Trip Overview

Average ticket price$62
Average bus trip duration12h 20m
Number of daily buses5
Earliest bus departure1:10am
Distance358 miles (576 km)
Latest bus departure5:00pm

Gainesville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Gainesville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Gainesville to Greenville.

From cheap bus tickets to more luxurious buses traveling from Gainesville to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Gainesville, FL - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/17
$43
09/18
No data
Today
No data
09/20
No data
09/21
No data
09/22
No data
09/23
$43
09/24
No data
busbud logoThe cheapest trip from Gainesville, FL to Greenville, SC was searched and found on Sep 17, 2025 with a price of $43

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Gainesville, FL to Greenville, SC, as early as possible.

You can expect to pay from $43 to $76 for a bus ticket from Gainesville, FL to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $43 which is on 2025-09-23.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Gainesville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Gainesville to Greenville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Gainesville to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Gainesville to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Gainesville, FL by bus?

Bus from Greenville, SC to Gainesville, FL

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Gainesville

Buses Leaving from Gainesville

Buses Going to Gainesville

Popular Buses Connecting Greenville

Buses Leaving from Greenville

Buses Going to Greenville