Next departures for Ann Arbor to St. Louis on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Ann Arbor
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Ann Arbor
Gateway Station
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Ann Arbor
Gateway Station
No tags
Last refresh of the prices: Yesterday at 7:49 PM EST.
Compare 2 ways to go from Ann Arbor to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach St. Louis. The journey takes about 12 hours 53 minutes and with fares starting at just $75, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Ann Arbor to St. Louis by bus
What is the distance between Ann Arbor and St. Louis?
Ann Arbor and St. Louis are 423 miles (682 km) apart.
What are the departure and arrival stations when taking the bus from Ann Arbor to St. Louis?
Buses going from Ann Arbor to St. Louis begin their journey at Train Station and reach their destination at Gateway Station.
What are the best sights and things to do in St. Louis?
Once in St. Louis, you can start exploring the city and discover its surroundings. The top sights and things to do are Saint Louis Science Center, St. Louis Cardinals, Powell Symphony Hall, Saint Louis Zoo and Old St. Louis County Courthouse.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/18
$139
11/19
$72
Today
$78
11/21
$153
11/22
$81
11/23
No data
11/24
No data
11/25
$107
The cheapest trip from Ann Arbor to St. Louis was searched and found on Nov 19, 2025 with a price of $72
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Ann Arbor to St. Louis, as early as possible.
You can expect to pay from $72 to $172 for a bus ticket from Ann Arbor to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $81 which is on 2025-11-22.
What's the cheapest way to go from Ann Arbor to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Ann Arbor to St. Louis was searched and found on Nov 19, 2025 with a price of $72
The bus is the cheapest travel choice for this destination
