How much is the train ticket from Rome to Isernia?

The cheapest train tickets from Rome to Isernia start from R 312. The average price for this train route is around R 370. Busbud recommends booking your tickets in advance for a better chance to secure the lowest possible price.

How long is the train journey from Rome to Isernia?

The average train journey time from Rome to Isernia is 2h 16m, covering a distance of 148 km. The quickest train can get you there in 2h 5m and is operated by Trenitalia .

Which train operators serve the Rome to Isernia route?

Several major train operators run on this route, with 2 trains available per day.

What are the earliest and latest departure times for the train from Rome to Isernia?

The earliest train from Rome to Isernia departs at 09:07. And the latest train departs at 20:14.

Train Rome to Isernia from R 286

Next train departures

Next departures from Rome to Isernia on 18 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest

Next departures from Rome to Isernia on 19 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest

Next departures from Rome to Isernia on 20 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest

Next departures from Rome to Isernia on 21 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest

Next departures from Rome to Isernia on 22 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest
	Train	17:40	Termini	2h 15m	19:55	Isernia	No tags

Next departures from Rome to Isernia on 23 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest

Next departures from Rome to Isernia on 24 March
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Train	09:07	Termini	2h 8m	11:15	Isernia	CheapestFastest

Last refresh of the prices: Today at 1:41 AM CET.

Compare 2 ways to travel from Rome to Isernia

We recommend taking the train

Among the sustainable travel choices, the Train stands out as a good way to reach Isernia. The journey takes about 2 hours 16 minutes and with fares starting at just R 312, it presents an excellent value for a comfortable ride.

2train per day

2h 16mAverage duration

148 kmDistance

4kgCO₂ emissions

	Average price	Average duration	CO₂ emissions	Actions
Bus	Average priceR 206 - R 757	Average duration6h 44m	CO₂ emissions 4kg CO₂e
Train	Average priceR 312 - R 512	Average duration2h 16m	CO₂ emissions 4kg CO₂e

Where are the popular train stations and stops in Rome and Isernia?

Rome

A
Termini
Piazza dei Cinquecento 1, 00185 Roma RM, Italy
Visit page
B
Rome Tiburtina Bus Station
Largo Guido Mazzoni, 3, 00162 Roma, Italy
Visit page
C
Rome Fiumicino Airport (FCO), Train station
Fiumicino Aeroporto, 00054 Fiumicino RM, Italy
Visit page
D
Roma S. Pietro
Roma S.Pietro, 00165 Roma RM, Italy
Visit page
E
Roma Trastevere
Roma Trastevere Railway Station, 00152 Roma RM, Italy
Visit page
F
Cesano di Roma
Cesano Di Roma, 00123 Roma RM, Italy
Visit page

Isernia

A
Isernia
Piazza della Repubblica, 9, 86170 Isernia IS, Italy
Visit page

Train Companies

Trenitalia

4/558 reviews

Staff4.6

Timeliness4.6

Cleanliness4.7

WiFi2.5

Based on 58 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the departure location but often complained about the Wi-Fi. Trenitalia ticket prices on this trip start at R 312

IT train companies: Amtrak, Trenitalia, Renfe, VIA Rail Canada, Deutsche Bahn, Deutsche Bahn ICE, RegioJet

Frequently asked questions about travelling from Rome to Isernia by train

Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

How much is the train ticket from Rome to Isernia?
The cheapest train tickets from Rome to Isernia start from R 312. The average price for this train route is around R 370. Busbud recommends booking your tickets in advance for a better chance to secure the lowest possible price.
How long is the train journey from Rome to Isernia?
The average train journey time from Rome to Isernia is 2h 16m, covering a distance of 148 km. The quickest train can get you there in 2h 5m and is operated by Trenitalia.
Which train operators serve the Rome to Isernia route?
Several major train operators run on this route, with 2 trains available per day.
What are the earliest and latest departure times for the train from Rome to Isernia?
The earliest train from Rome to Isernia departs at 09:07. And the latest train departs at 20:14.

Find cheapest prices for trains

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

16/03

R 288

17/03

R 288

Today

R 288

19/03

R 290

20/03

R 288

21/03

R 288

22/03

R 288

23/03

R 295

The cheapest trip from Rome to Isernia was searched and found on 16 Mar 2026 with a price of R 288

To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Rome to Isernia as early as possible.

You can expect to pay from R 288 to R 295 for a train ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at R 288, which is on 2026-03-20.