Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Mainz | Brussels Airport | No tags | ||||
| Bus | Mainz | Brussels-North (Gare du Nord) | No tags | ||||
| Bus | Mainz | Brussels-North (Gare du Nord) | No tags | ||||
| Bus | Mainz | Brussels Airport | No tags | ||||
| Bus | Mainz | Brussels Airport | No tags |
Compare 3 ways to travel from Mainz to Brussels
Among the sustainable travel choices, the carpool stands out as a good way to reach Brussels. The journey takes about 4 hours and with fares starting at just R 628, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mainz and Brussels?
Stops in Mainz
- A
Mainz
Hechtsheimer Str. 65, 55131 Mainz, Germany - B
Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite
Kaiser-Wilhelm-Ring 16 (gegenüberliegende Straßenseite), 55118 Mainz - Cflibco.com bus stop, Kaiser-Wilhelm-Ring, 55118 Mainz, Germany
Stops in Brussels
- ARue de France 85, 1060 Saint-Gilles, Belgium
- BBoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- CPachecolaan 5, 1000 Brussel, Belgium
- D
Centrale
Rue de Loxum 5, 1000 Bruxelles, Belgium
Compare bus companies
Based on 11424 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at R 504
Frequently asked questions about travelling from Mainz to Brussels by bus
How much does a bus ticket from Mainz to Brussels cost?
The bus ticket price from Mainz to Brussels starts at R 504. The best way to find cheap bus tickets from Mainz to Brussels is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Mainz to Brussels?
The average travel time between Mainz and Brussels is around 7h 30m, although the fastest bus will take about 5h 45m. This is the time it takes to travel the 295 km that separates the two cities.
How many daily bus connections are there between Mainz and Brussels?
The number of buses from Mainz to Brussels can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Mainz to Brussels by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Mainz to Brussels?
When taking the bus from Mainz to Brussels, you can travel comfortably and safely with FlixBus.
What are the departure and arrival stations when taking the bus from Mainz to Brussels?
Buses travelling between Mainz and Brussels leave from Mainz or Mainz- Kaiser-Wilhelm-Ring 16- gegenüberliegende Straßenseite and arrive at Brussels South (Gare du Midi), Brux-Nord, Congrès.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mainz to Brussels was searched and found on 28 Nov 2025 with a price of R 439To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mainz to Brussels as early as possible.
You can expect to pay from R 439 to R 710 for a bus ticket from Mainz to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at R 439, which is on 2025-11-28.