Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Syracuse (Regional Transportation Center) | Indianapolis Bus Station | CheapestFastest | ||||
| Bus | Syracuse (Regional Transportation Center) | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Syracuse (Regional Transportation Center) | Downtown Transit Center | No tags |
Last refresh of the prices: Yesterday at 09:41 EST.
Compare 2 ways to travel from Syracuse to Indianapolis
Among the sustainable travel choices, the Bus stands out as a good way to reach Indianapolis. The journey takes about 1 day, 20 minutes and with fares starting at just £72, it presents an excellent value for a comfortable ride.
Where are the popular stops in Syracuse and Indianapolis?
Stops in Syracuse
- A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208 - CBus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
- D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA - E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA - F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA
Stops in Indianapolis
- A350 S Illinois St, Indianapolis, IN 46225
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Frequently asked questions about travelling by bus from Syracuse, US to Indianapolis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Syracuse to Indianapolis?
The cheapest coach tickets from Syracuse to Indianapolis start from £72. The average price for this route is around £164. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Syracuse to Indianapolis?
The average bus journey time from Syracuse to Indianapolis is 1d , covering a distance of 565 miles. The fastest bus can take you there in 21h 40m and is operated by Greyhound.
Which bus companies service the Syracuse to Indianapolis route?
What is the earliest and latest departure time for the bus from Syracuse to Indianapolis?
The earliest bus departs from Syracuse to Indianapolis at 01:15. And the latest bus departs at 21:00.
What are the CO₂ emissions for the bus trip from Syracuse to Indianapolis?
A bus journey from Syracuse to Indianapolis produces an estimated 23 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Syracuse to Indianapolis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which company has the best Wi-Fi from Syracuse to Indianapolis?
Based on Busbud reviews, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company offers the most punctual service from Syracuse to Indianapolis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Syracuse to Indianapolis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Syracuse, US to Indianapolis was searched and found on 20 Jan 2026 with a price of £93To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Indianapolis as early as possible.
You can expect to pay from £93 to £191 for a bus ticket from Syracuse, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at £93, which is on 2026-01-20.
What's the cheapest way to go from Syracuse, US to Indianapolis?
The Bus is the cheapest travel choice for this destination
