Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Viale Toselli (Penny Market) | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags | ||||
| Bus | Siena Train Station | Terminal Bus Palermo | No tags |
Get from Siena to Palermo
The journey takes about 16 hours, and with fares starting at just £42, it presents an excellent value for a comfortable ride.
Where are the popular stops in Siena and Palermo?
Stops in Siena
- APiazza Antonio Gramsci, 53100 Siena SI, Italy
- B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- EVia Paolo Balsamo, 21, 90123 Palermo, Italy
- F
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy
Compare bus companies
Based on 12362 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at £42
Frequently asked questions about travelling by bus from Siena to Palermo
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Siena to Palermo?
The cheapest coach tickets from Siena to Palermo start from £42. The average price for this route is around £53. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Siena to Palermo?
The average bus journey time from Siena to Palermo is 16h, covering a distance of 376 miles. The fastest bus can take you there in 16h and is operated by FlixBus.
Which bus companies service the Siena to Palermo route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Siena to Palermo?
The earliest bus departs from Siena to Palermo at 14:51. And the latest bus departs at 22:25.
What are the CO₂ emissions for the bus trip from Siena to Palermo?
A bus journey from Siena to Palermo produces an estimated 15 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Siena to Palermo was searched and found on 27 Mar 2026 with a price of £39To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Siena to Palermo as early as possible.
You can expect to pay from £39 to £50 for a bus ticket from Siena to Palermo based on the last 2 days. You can expect to find the cheapest price for the trip at £39, which is on 2026-03-27.
