Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Rome Tiburtina Bus Station | Florenc | CheapestFastest |
Last refresh of the prices: Last Monday at 10:33 CET.
Compare 2 ways to travel from Rome to Prague
Among the sustainable travel choices, the carpool stands out as a good way to reach Prague. The journey takes about 14 hours and with fares starting at just £50, it presents an excellent value for a comfortable ride.
| Average price | Average duration | CO₂ emissions | Actions | |
|---|---|---|---|---|
| Average price£45 - £194 | Average duration1d | 23kg CO₂e | ||
Carpool | Average price£50 - £58 | Average duration14h | 39kg CO₂e |
Where are the popular stops in Rome and Prague?
Stops in Rome
- ALargo Guido Mazzoni, 3, 00162 Roma, Italy
- D
Castro Pretorio
Viale Castro Pretorio 76, 00185 Roma, Italy - E
Roma
- F
Anagnina
Via Vincenzo Giudice, 00173 Roma RM, Italy
Stops in Prague
- A
Zličín
Drahoňovského, 163 00 Praha 17, Czech Republic - BAviatická, 161 08, Praha 6, Czechia
- CTomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- EKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- F300/8 Wilsonova, 110 00 Praha, Czechia
Compare bus companies
Frequently asked questions about travelling by bus from Rome to Prague
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Rome to Prague?
The cheapest coach tickets from Rome to Prague start from £45. The average price for this route is around £105. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Rome to Prague?
The average bus journey time from Rome to Prague is 1d , covering a distance of 572 miles. The fastest bus can take you there in 20h 10m and is operated by RegioJet.
Which bus companies service the Rome to Prague route?
What is the earliest and latest departure time for the bus from Rome to Prague?
The earliest bus departs from Rome to Prague at 01:00. And the latest bus departs at 23:50.
What are the CO₂ emissions for the bus trip from Rome to Prague?
A bus journey from Rome to Prague produces an estimated 23 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Rome to Prague?
According to Busbud customers, the highest-rated bus company on this route is RegioJet, with an average rating of 4.1 out of 5 stars based on 1057 reviews.
Which company has the best Wi-Fi from Rome to Prague?
Based on Busbud reviews, the bus company RegioJet has the best Wi-Fi rating with a score of 3.8.
Which bus company offers the most punctual service from Rome to Prague?
According to Busbud traveller reviews, the most punctual bus company on this route is RegioJet, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Rome to Prague?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is RegioJet, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rome to Prague was searched and found on 6 Dec 2025 with a price of £57To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Prague as early as possible.
You can expect to pay from £57 to £163 for a bus ticket from Rome to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at £57, which is on 2025-12-06.
