Find coaches from Port Saint Lucie to Charleston, SC, US

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Previously seen journeys

One passenger / one way

  • Departure time: 6 September at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: 6 September at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 6 September at
    Departure city: Port Saint Lucie
    Departure location: Port St. Lucie (Park & Ride)
    Arrival time: 7 September at
    Destination city: Charleston
    Destination location: 4565 Gaynor Ave, North Charleston
    Operated by: FlixBus + Greyhound
    FlixBus + Greyhound
    Vehicle: BusDuration:

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Bus Port Saint Lucie to Charleston, SC, US: Trip Overview

Average ticket priceUS$128
Average bus trip duration22h 5m
Number of daily buses1
Earliest bus departure01:40
Distance388 miles
Latest bus departure15:45

Port Saint Lucie to Charleston Bus

With Busbud, comparing and booking tickets for a bus from Port Saint Lucie to Charleston is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Port Saint Lucie to Charleston will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Port Saint Lucie to Charleston, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Port Saint Lucie - Charleston, SC, US

  1. How far is Charleston from Port Saint Lucie by coach?

    The distance between Port Saint Lucie and Charleston by coach is approximately 380 miles (613 km).

  2. Is there a way to reach Charleston from Port Saint Lucie without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
02/09
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03/09
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Today
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05/09
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06/09
US$102
07/09
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08/09
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09/09
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busbud logoThe cheapest trip from Port Saint Lucie to Charleston, SC, US was searched and found on 6 Sept 2025 with a price of US$102

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Charleston, SC, US as early as possible.

You can expect to pay from US$102 to US$102 for a bus ticket from Port Saint Lucie to Charleston, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$102, which is on 2025-09-06.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Port Saint Lucie to Charleston.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Port Saint Lucie to Charleston, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Port Saint Lucie to Charleston that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Port Saint Lucie to Charleston, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Port Saint Lucie by bus?

Bus from Charleston, SC, US to Port Saint Lucie

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