Previously seen journeys
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal Bus Palermo | Siena Train Station | No tags | ||||
| Bus | Terminal Bus Palermo | Siena Train Station | No tags | ||||
| Bus | Terminal Bus Palermo | Viale Toselli (Penny Market) | No tags | ||||
| Bus | Terminal Bus Palermo | Siena Train Station | No tags | ||||
| Bus | Terminal Bus Palermo | Siena Train Station | No tags |
Get from Palermo to Siena
The journey takes about 16 hours 20 minutes, and with fares starting at just £37, it presents an excellent value for a comfortable ride.
Where are the popular stops in Palermo and Siena?
Stops in Palermo
- AVia Tommaso Fazello, 16, 90123 Palermo PA, Italy
- BPunta Raisi, 90145, Palermo
- CPiazza Cairoli, 8-14, 90123 Palermo, Italy
- D90143 Palermo PA, Italy
- EVia Paolo Balsamo, 21, 90123 Palermo, Italy
- F
Via Paolo Balsamo, 31
Via Paolo Balsamo, 23-31, 90123 Palermo, Italy
Stops in Siena
- APiazza Antonio Gramsci, 53100 Siena SI, Italy
- B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
Compare bus companies
Based on 12354 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi‑Fi. FlixBus ticket prices on this trip start at £37
Frequently asked questions about travelling by bus from Palermo to Siena
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Palermo to Siena?
The cheapest coach tickets from Palermo to Siena start from £37. The average price for this route is around £44. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Palermo to Siena?
The average bus journey time from Palermo to Siena is 16h 20m, covering a distance of 376 miles. The fastest bus can take you there in 16h 20m and is operated by FlixBus.
Which bus companies service the Palermo to Siena route?
Several major bus companies operate on this route with 2 buses available per day.
What is the earliest and latest departure time for the bus from Palermo to Siena?
The earliest bus departs from Palermo to Siena at 15:25. And the latest bus departs at 17:10.
What are the CO₂ emissions for the bus trip from Palermo to Siena?
A bus journey from Palermo to Siena produces an estimated 15 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Palermo to Siena was searched and found on 24 Mar 2026 with a price of £36To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Palermo to Siena as early as possible.
You can expect to pay from £36 to £87 for a bus ticket from Palermo to Siena based on the last 2 days. You can expect to find the cheapest price for the trip at £41, which is on 2026-03-25.
What's the cheapest way to go from Palermo to Siena?
The Bus is the cheapest travel choice for this destination
