Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Bus Station | Downtown Transit Center | Cheapest | ||||
 | Bus | Bus Station | Indianapolis Bus Station | Fastest |
Last refresh of the prices: Last Sunday at 12:43 EST.
Get from Myrtle Beach to Indianapolis
The journey takes about 22 hours 10 minutes, and with fares starting at just £84, it presents an excellent value for a comfortable ride.
Where are the popular stops in Myrtle Beach and Indianapolis?
Compare bus companies
Based on 87488 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £84
Frequently asked questions about travelling by bus from Myrtle Beach to Indianapolis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Myrtle Beach to Indianapolis?
The cheapest coach tickets from Myrtle Beach to Indianapolis start from £84. The average price for this route is around £133. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Myrtle Beach to Indianapolis?
The average bus journey time from Myrtle Beach to Indianapolis is 22h 10m, covering a distance of 580 miles. The fastest bus can take you there in 22h 10m and is operated by Greyhound.
Which bus companies service the Myrtle Beach to Indianapolis route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from Myrtle Beach to Indianapolis?
The earliest bus departs from Myrtle Beach to Indianapolis at 13:55. And the latest bus departs at 13:55.
What are the CO₂ emissions for the bus trip from Myrtle Beach to Indianapolis?
A bus journey from Myrtle Beach to Indianapolis produces an estimated 23 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Myrtle Beach to Indianapolis was searched and found on 6 Jan 2026 with a price of £92To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Myrtle Beach to Indianapolis as early as possible.
You can expect to pay from £92 to £145 for a bus ticket from Myrtle Beach to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at £92, which is on 2026-01-12.
