Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Aéroport LYS | Siena Train Station | Cheapest | ||||
| Bus | Perrache | Siena Train Station | Fastest |
Last refresh of the prices: Today at 00:50 CET.
Get from Lyon to Siena
The journey takes about 15 hours 25 minutes, and with fares starting at just £43, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lyon and Siena?
Stops in Lyon
- BRue de Esplanade, 69002 Lyon, France
- C
Lyon
8 Rue de la Paix, 69700 Givors, France - D
Quai de Saoune
4 Cours de Verdun Rambaud, 69002 Lyon, France - E
Villeurbanne INSA
20 Avenue Albert Einstein, 69100 Villeurbanne, France - FLes Charrières, 69570 Dardilly, France
Stops in Siena
- APiazza Antonio Gramsci, 53100 Siena SI, Italy
- B
Via Sallustio Bandini, 21
Via Sallustio Bandini, 21, 53100 Siena SI, Italy - C
Via Giuseppe Mazzini, 58
Via Giuseppe Mazzini, 58, 53100 Siena SI, Italy - D
Via Riccardo Lombardi, 42
Via Riccardo Lombardi, 42, 53100 Siena SI, Italy - E
Torre Fiorentina
Torre Fiorentina, 53100 Siena SI, Italy - F
Siena Zona Industriale
Siena FS, 53100 Siena SI, Italy
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Frequently asked questions about travelling by bus from Lyon to Siena
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Lyon to Siena?
The cheapest coach tickets from Lyon to Siena start from £43. The average price for this route is around £75. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Lyon to Siena?
The average bus journey time from Lyon to Siena is 15h 25m, covering a distance of 350 miles. The fastest bus can take you there in 11h 20m and is operated by FlixBus.
Which bus companies service the Lyon to Siena route?
What is the earliest and latest departure time for the bus from Lyon to Siena?
The earliest bus departs from Lyon to Siena at 01:15. And the latest bus departs at 23:30.
What are the CO₂ emissions for the bus trip from Lyon to Siena?
A bus journey from Lyon to Siena produces an estimated 14 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Lyon to Siena?
According to Busbud customers, the highest-rated bus company on this route is Itabus, with an average rating of 3.8 out of 5 stars based on 951 reviews.
Which company has the best Wi-Fi from Lyon to Siena?
Based on Busbud reviews, the bus company Itabus has the best Wi-Fi rating with a score of 3.0.
Which bus company offers the most punctual service from Lyon to Siena?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Lyon to Siena?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Itabus, with a cleanliness rating of 4.3 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lyon to Siena was searched and found on 9 Dec 2025 with a price of £44To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lyon to Siena as early as possible.
