Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Lugano | Prague (Central Bus Station Florenc) | Cheapest | |||||
| Lugano | Prague (Main Railway Station) | Fastest | |||||
 | Via Giacomo E Filippo Ciani | Florenc | No tags | |||||
| Lugano | PRG Airport | No tags | |||||
| Lugano | PRG Airport | No tags |
Last refresh of the prices: Yesterday at 8:57 PM CEST.
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Bus Lugano to Prague: Trip Overview
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Lugano to Prague Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Lugano to Prague.
We make sure you can find a bus service from Lugano to Prague from the most reliable bus companies operating this trip.
Discover how much the bus trip from Lugano to Prague will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Lugano and Prague?
Frequently asked questions on the trip Lugano - Prague
How far is Lugano from Prague?
The distance covered from Lugano to Prague is 609 km (378 miles).
What are the departure and arrival locations for buses traveling from Lugano to Prague?
Buses traveling this route start their trip at Arrêt D'autobus Lugano, in Lugano, and end it at Florenc, in Prague.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lugano to Prague was searched and found on Sep 25, 2025 with a price of US$62To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lugano to Prague, as early as possible.
You can expect to pay from US$62 to US$152 for a bus ticket from Lugano to Prague based on the last 2 days. You can expect to find the cheapest price for the trip at US$70 which is on 2025-09-28.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Lugano to Prague but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Lugano to Prague, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Lugano to Prague will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Lugano to Prague, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
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