How much does a bus ticket from Santa Ana to San Diego cost?

The bus ticket price from Santa Ana to San Diego starts at R 346. The best way to find cheap bus tickets from Santa Ana to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the bus ride from Santa Ana to San Diego?

The average travel time between Santa Ana and San Diego is around 2h 5m, although the fastest bus will take about 1h 10m. This is the time it takes to travel the 133 km that separates the two cities.

How many daily bus connections are there between Santa Ana and San Diego?

The number of buses from Santa Ana to San Diego can differ depending on the day of the week. On average, there are 25 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santa Ana to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.

Which bus companies travel from Santa Ana to San Diego?

When taking the bus from Santa Ana to San Diego, you can travel comfortably and safely with Los Limousines, FlixBus, Greyhound.

What are the departure and arrival stations when taking the bus from Santa Ana to San Diego?

Buses travelling between Santa Ana and San Diego leave from Santa Ana Greyhound Bus Station or 602 S Main St and arrive at Mission Valley Sheraton, Old Town Courtyard Marriot, Downtown Holiday Inn.

Bus Santa Ana to San Diego from R 211 | Refundable Tickets

Next bus departures

Next departures from Santa Ana to San Diego on 14 November
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	20:30	Santa Ana Bus Station	1h 15m	21:45	UCSD Health La Jolla Station	CheapestFastest
Bus	21:40	Anaheim Regional Transportation Intermodal Center	2h 10m	23:50	Greyhound Bus Stop	No tags
Bus	20:30	Santa Ana Bus Station	1h 45m	22:15	Downtown SD (Seaport)	No tags
Bus	22:45	Santa Ana E Santa Ana Blvd	1h 30m	00:15	Cross Border Xpress CBX (USA)	No tags
Bus	22:05	Santa Ana Bus Station	1h 45m	23:50	Greyhound Bus Stop	No tags

Next departures from Santa Ana to San Diego on 15 November
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	14:35	Santa Ana Bus Station	1h 50m	16:25	San Diego (Old Town-FlixBus)	Cheapest
Bus	20:30	Santa Ana Bus Station	1h 15m	21:45	UCSD Health La Jolla Station	Fastest
Bus	09:40	Anaheim Regional Transportation Intermodal Center	2h 5m	11:45	Greyhound Bus Stop	No tags
Bus	14:35	Santa Ana Bus Station	1h 20m	15:55	UCSD Health La Jolla Station	No tags
Bus	05:55	Santa Ana E Santa Ana Blvd	2h 35m	08:30	Cross Border Xpress CBX (USA)	No tags

Next departures from Santa Ana to San Diego on 16 November
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	20:20	Santa Ana Bus Station	1h 20m	21:40	UCSD Health La Jolla Station	Cheapest
Bus	14:25	Santa Ana Bus Station	1h 20m	15:45	UCSD Health La Jolla Station	Fastest
Bus	15:25	Anaheim Regional Transportation Intermodal Center	1h 50m	17:15	San Diego (Old Town-FlixBus)	No tags
Bus	09:40	Anaheim Regional Transportation Intermodal Center	2h 5m	11:45	Greyhound Bus Stop	No tags
Bus	05:55	Santa Ana E Santa Ana Blvd	2h 35m	08:30	Cross Border Xpress CBX (USA)	No tags

Next departures from Santa Ana to San Diego on 20 November
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	20:30	Santa Ana Bus Station	1h 15m	21:45	UCSD Health La Jolla Station	CheapestFastest
Bus	09:40	Anaheim Regional Transportation Intermodal Center	2h 5m	11:45	Greyhound Bus Stop	No tags
Bus	14:25	Santa Ana Bus Station	1h 45m	16:10	San Diego (Old Town-FlixBus)	No tags
Bus	05:55	Santa Ana E Santa Ana Blvd	2h 35m	08:30	Cross Border Xpress CBX (USA)	No tags
Bus	21:40	Anaheim Regional Transportation Intermodal Center	2h 10m	23:50	Greyhound Bus Stop	No tags

Last refresh of the prices: Yesterday at 11:00 AM PST.

Get from Santa Ana to San Diego

This route is served by bus only

The journey takes about 2 hours 5 minutes, and with fares starting at just R 346, it presents an excellent value for a comfortable ride.

25bus per day

2h 5mAverage duration

158 kmDistance

4kgCO₂ emissions

Compare bus companies

Los Limousines

3.5/5265 reviews

Staff4.3

Timeliness2.8

Cleanliness3.9

WiFi2.8

Users have reported that the bus service offers a comfortable ride with friendly and helpful drivers. However, there were some challenges in identifying the departure point on tickets, leading to confusion for travelers. Additionally, there was an instance of delayed arrival without immediate customer support over the phone.

Los Limousines Santa Ana San Diego recent customer reviews

The trip was very pleasant. They helped me find the departure point over the phone. The only problem was that I didn't see the departure point identified on the ticket.

Gloria Juambelz J.

4 July 2025

The bus came late. Like 30 minutes and I called several times and nobody answered me until 15 minutes after. The bus is comfortable and the driver was extremely nice and kind.

Nury D.

10 May 2025

40 minutes delayed! Almost lost my connection flight

Ernesto L.

11 September 2025

FlixBus

3.5/511 312 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

Greyhound

3.5/587 371 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

Based on 87371 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 400

Greyhound Santa Ana San Diego recent customer reviews

I had to wait for 1hour30 to be able getting in the bus because it hadn’t finished the trip to LA.

Dan B.

25 September 2018

Bus was 40 minutes late departing. We nearly missed our flight.

Scott B.

29 July 2018

It was cool

Aarica M.

21 January 2018

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Santa Ana and San Diego?

Stops in Santa Ana

A - Santa Ana Greyhound Bus Station

B - 602 S Main St

Stops in San Diego

A - Mission Valley Sheraton

B - Old Town Courtyard Marriot

C - Downtown Holiday Inn

D - Greyhound Station

E - Market St. & Park Blvd

F - San Ysidro McDonald's

Frequently asked questions about travelling from Santa Ana, US to San Diego, CA, US by bus

How much does a bus ticket from Santa Ana to San Diego cost?
The bus ticket price from Santa Ana to San Diego starts at R 346. The best way to find cheap bus tickets from Santa Ana to San Diego is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Santa Ana to San Diego?
The average travel time between Santa Ana and San Diego is around 2h 5m, although the fastest bus will take about 1h 10m. This is the time it takes to travel the 133 km that separates the two cities.
How many daily bus connections are there between Santa Ana and San Diego?
The number of buses from Santa Ana to San Diego can differ depending on the day of the week. On average, there are 25 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santa Ana to San Diego by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Santa Ana to San Diego?
When taking the bus from Santa Ana to San Diego, you can travel comfortably and safely with Los Limousines, FlixBus, Greyhound.
What are the departure and arrival stations when taking the bus from Santa Ana to San Diego?
Buses travelling between Santa Ana and San Diego leave from Santa Ana Greyhound Bus Station or 602 S Main St and arrive at Mission Valley Sheraton, Old Town Courtyard Marriot, Downtown Holiday Inn.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/11

R 325

13/11

R 255

Today

R 281

15/11

R 281

16/11

R 246

17/11

R 237

18/11

R 229

19/11

R 229

The cheapest trip from Santa Ana, US to San Diego, CA, US was searched and found on 18 Nov 2025 with a price of R 229

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Diego, CA, US as early as possible.

You can expect to pay from R 229 to R 751 for a bus ticket from Santa Ana, US to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 229, which is on 2025-11-18.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.