How much does a bus ticket from San Diego to Santa Ana cost?

The bus ticket price from San Diego to Santa Ana starts at R 353. The best way to find cheap bus tickets from San Diego to Santa Ana is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the bus ride from San Diego to Santa Ana?

The average travel time between San Diego and Santa Ana is around 2h 5m, although the fastest bus will take about 1h 15m. This is the time it takes to travel the 133 km that separates the two cities.

How many daily bus connections are there between San Diego and Santa Ana?

The number of buses from San Diego to Santa Ana can differ depending on the day of the week. On average, there are 20 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Diego to Santa Ana by comparing and selecting the bus that fits your travel style and budget on Busbud.

Which bus companies travel from San Diego to Santa Ana?

When taking the bus from San Diego to Santa Ana, you can travel comfortably and safely with Los Limousines, FlixBus, Greyhound.

What are the departure and arrival stations when taking the bus from San Diego to Santa Ana?

Buses travelling between San Diego and Santa Ana leave from Mission Valley Sheraton or Old Town Courtyard Marriot and arrive at Santa Ana Greyhound Bus Station, 602 S Main St.

Bus San Diego to Santa Ana from R 245 | Refundable Tickets

Next bus departures

Next departures from San Diego to Santa Ana on 14 November
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	06:45	Greyhound Bus Stop	1h 55m	08:40	Santa Ana Bus Station	Cheapest
Bus	16:15	UCSD Health La Jolla Station	1h 15m	17:30	UC Irvine (Crawford Hall)	Fastest
Bus	12:15	San Diego (Old Town-FlixBus)	2h 30m	14:45	Anaheim Regional Transportation Intermodal Center	No tags
Bus	19:35	Greyhound Bus Stop	2h	21:35	Anaheim Regional Transportation Intermodal Center	No tags
Bus	08:30	Cross Border Xpress CBX (USA)	2h 30m	11:00	Santa Ana E Santa Ana Blvd	No tags
Bus	12:15	San Diego (Old Town-FlixBus)	2h 5m	14:20	UC Irvine (Crawford Hall)	No tags
Bus	19:35	Greyhound Bus Stop	1h 45m	21:20	Santa Ana Bus Station	No tags
Bus	09:30	Cross Border Xpress CBX (USA)	5h 35m	15:05	Santa Ana E Santa Ana Blvd	No tags

Next departures from San Diego to Santa Ana on 15 November
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	08:20	San Diego (Old Town-FlixBus)	2h	10:20	Anaheim Regional Transportation Intermodal Center	Cheapest
Bus	16:15	UCSD Health La Jolla Station	1h 15m	17:30	UC Irvine (Crawford Hall)	Fastest
Bus	12:15	San Diego (Old Town-FlixBus)	2h 30m	14:45	Anaheim Regional Transportation Intermodal Center	No tags
Bus	19:35	Greyhound Bus Stop	2h	21:35	Anaheim Regional Transportation Intermodal Center	No tags
Bus	02:00	Cross Border Xpress CBX (USA)	1h 45m	03:45	Santa Ana E Santa Ana Blvd	No tags
Bus	12:15	San Diego (Old Town-FlixBus)	2h 5m	14:20	UC Irvine (Crawford Hall)	No tags
Bus	06:45	Greyhound Bus Stop	1h 55m	08:40	Santa Ana Bus Station	No tags
Bus	08:30	Cross Border Xpress CBX (USA)	2h 30m	11:00	Santa Ana E Santa Ana Blvd	No tags

Last refresh of the prices: Last Monday at 1:07 PM PST.

Get from San Diego to Santa Ana

This route is served by bus only

The journey takes about 2 hours 5 minutes, and with fares starting at just R 353, it presents an excellent value for a comfortable ride.

20bus per day

2h 5mAverage duration

122 kmDistance

3kgCO₂ emissions

Compare bus companies

Los Limousines

3.5/5265 reviews

Staff4.3

Timeliness2.8

Cleanliness3.9

WiFi2.8

Based on 265 reviews, the company was rated 3.4 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. Los Limousines ticket prices on this trip start at R 761

Los Limousines San Diego Santa Ana recent customer reviews

The bus driver this particular ride was very rude. It is not our fault she has to work driving for a bus company while me and the other passengers are enjoying our vacation.

Vianey P.

30 July 2025

the bus was early 1/2 hour and arrived to the destination 15 minutes early this was nice.

Rafael G.

14 April 2025

FlixBus

3.5/511 305 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

Greyhound

3.5/587 371 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

WiFi2.4

Based on 87371 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 379

Greyhound San Diego Santa Ana recent customer reviews

Already filled a complaint against your bus company with Department of Consumer Affairs, Department of Transportation, and Better Business Bureau.

Peter N.

21 October 2018

I had to wait more than 3 hours because my scheduled bus was delayed. I almost cured out loud.

Toan T.

11 August 2018

Price and people were good but : Old bus No wifi Must print ticket .... come on, we are in 2017!!!! Even at home in Quebec, we can show the electronic ticket in greyhounds bus!!!

Isabelle R.

14 June 2017

Las Vegas Shuttles

3.5/548 reviews

Staff4.5

Timeliness2.2

Cleanliness4.8

WiFi3.2

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in San Diego and Santa Ana?

Stops in San Diego

A - Mission Valley Sheraton

B - Old Town Courtyard Marriot

C - Downtown Holiday Inn

D - Greyhound Station

E - Market St. & Park Blvd

F - San Ysidro McDonald's

Stops in Santa Ana

A - Santa Ana Greyhound Bus Station

B - 602 S Main St

Frequently asked questions about travelling from San Diego, CA, US to Santa Ana, US by bus

How much does a bus ticket from San Diego to Santa Ana cost?
The bus ticket price from San Diego to Santa Ana starts at R 353. The best way to find cheap bus tickets from San Diego to Santa Ana is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from San Diego to Santa Ana?
The average travel time between San Diego and Santa Ana is around 2h 5m, although the fastest bus will take about 1h 15m. This is the time it takes to travel the 133 km that separates the two cities.
How many daily bus connections are there between San Diego and Santa Ana?
The number of buses from San Diego to Santa Ana can differ depending on the day of the week. On average, there are 20 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Diego to Santa Ana by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from San Diego to Santa Ana?
When taking the bus from San Diego to Santa Ana, you can travel comfortably and safely with Los Limousines, FlixBus, Greyhound.
What are the departure and arrival stations when taking the bus from San Diego to Santa Ana?
Buses travelling between San Diego and Santa Ana leave from Mission Valley Sheraton or Old Town Courtyard Marriot and arrive at Santa Ana Greyhound Bus Station, 602 S Main St.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/11

R 350

12/11

R 376

Today

R 324

14/11

R 306

15/11

R 306

16/11

R 271

17/11

R 289

18/11

R 262

The cheapest trip from San Diego, CA, US to Santa Ana, US was searched and found on 18 Nov 2025 with a price of R 262

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Ana, US as early as possible.

You can expect to pay from R 262 to R 748 for a bus ticket from San Diego, CA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 262, which is on 2025-11-18.

Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.