Find coaches from Key West to Panama City, US

Previously seen journeys

Next departures from Key West to Panama City on 2 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
    		Caroline St
    		Panama City Beach StationNo tags
    Greyhound
      		Key West Bus Station
      		Panama City Beach StationNo tags
      Greyhound + FlixBus
        		Caroline St
        		Panama City Beach StationNo tags
        Greyhound
          		Key West Bus Station
          		Panama City Beach StationNo tags
          Greyhound
            		Key West Bus Station
            		Panama City Beach StationNo tags

            Accepted payments

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            Get from Key West to Panama City

            This route is served by bus only

            The journey takes about 22 hours, and with fares starting at just US$148, it presents an excellent value for a comfortable ride.

            1bus per day
            22hAverage duration
            742 kmDistance
            19kgCO₂ emissions

            Bus Key West to Panama City, US: Trip Overview

            Average ticket priceUS$148
            Average bus trip duration22h
            Number of daily buses1
            Earliest bus departure17:00
            Distance741 km

            Key West to Panama City Bus

            With Busbud, comparing and booking tickets for a bus from Key West to Panama City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            Bus service from Key West to Panama City will be provided by the most trusted bus companies.

            Whether it is cheap bus tickets or more luxurious buses going to Panama City from Key West, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip Key West - Panama City, US

            1. How much does a bus ticket from Key West to Panama City cost?

              The bus ticket price from Key West to Panama City starts at US$148. The best way to find cheap bus tickets from Key West to Panama City is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Key West to Panama City?

              The average travel time between Key West and Panama City is around 22h, although the fastest bus will take about 22h. This is the time it takes to travel the 733 km that separates the two cities.

            3. How many daily bus connections are there between Key West and Panama City?

              The number of buses from Key West to Panama City can differ depending on the day of the week. On average, there are 1 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Key West to Panama City by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Key West to Panama City?

              When taking the bus from Key West to Panama City, you can travel comfortably and safely with Greyhound, FlixBus.

            5. What are the departure and arrival stations when taking the bus from Key West to Panama City?

              Buses travelling between Key West and Panama City leave from Caroline St or EYW Airport and arrive at Panama City Greyhound Bus Station.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            30/10
            US$141
            31/10
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            Today
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            02/11
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            busbud logoThe cheapest trip from Key West to Panama City, US was searched and found on 30 Oct 2025 with a price of US$141

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Key West to Panama City, US as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from Key West to Panama City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            Much more than a mere vehicle taking you from Key West to Panama City, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Key West to Panama City.

            Make a music playlist for your bus ride from Key West to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.

            Did you know?

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Will you be returning to Key West by bus?

            Bus from Panama City, US to Key West

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